![]() ![]() Click here for Price and Turnaround Time. Clinicians currently using autologous stem cell or IRAP II™ System therapy should consider use of RenoVō ® to achieve similar or improved clinical outcomes. Severe combined immunodeficiency (SCID), an inherited condition primarily affecting Arabians, is characterized by an underdeveloped immune system that results in foals with elevated temperatures, respiratory stress, and diarrhea. Infection can come from: bacteria, viruses, fungus. RenoVō ® is cryopreserved and maintained frozen before use, so as to preserve beneficial proteins that may not survive lyophilization. An SCID foal will die within weeks but most likely before five months of age, because they can not fight off infection. ![]() The reproducibility of each donor tissue also offers a more homogeneous protein concentration and product consistency in comparison to other regenerative modalities. A PCR-based test for detection of the gene defect and the results from testing 250 randomly selected Arabian horses are described and the frequency of SCID. adenovirus, coronavirus, Rhodococcus equi. ![]() This immunodeficiency may occur in Arabian foals (or breeds carrying Arab bloodlines), and manifests clinically by susceptibility to viral, bacterial, fungal, and protozoal organisms (e.g. Further, cytokine and growth factor profiles can vary dramatically between patients for a selected autologous product. Severe combined immunodeficiency (SCID) is a fatal condition of both B (humoral) and T (cellular) cell dysfunction. Both male and female foals are equally affected. Affected foals do not survive past the first six months of life. Ready availability of a convenient allograft potentiates clinical use without the time lapse for culturing cells or harvest techniques required for autologous therapies. Phenotype: Severe combined immunodeficiency (SCID) foals are normal at birth but soon present signs such as elevated temperature, respiratory stress, and diarrhea at an early age, typically between 2-8 weeks of age. The use of equine amniotic tissue allografts to supplement and protect tissues in horses may be minimally invasive, safe, and offer a morbidity profile comparable to or better than those of existing modalities, including autologous stem cell or interleukin-1 receptor antagonist platforms (e.g., IRAP II™ System), while offering potentially superior clinical results. SCID in Arabian foals is caused by a frame-shift mutation in the gene encoding the catalytic subunit of DNA-dependent protein kinase ( Shin et al., 1997 Wiler et al. ![]()
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